Overfeeding gradually leads to increased fat mass. Arginine supplements prevented fat accumulation in rats fed high-calorie diets. In a study genetically obese rats were fed diets high or low in fat. Fat pad weights were 74 percent higher in rats fed a high-fat diet. Supplementing their diet with arginine reduced fat increase by 50 percent. Arginine treatments resulted in lower blood levels of leptin (weight controlling hormone), glucose, triglycerides, urea, glutamine and branched-chain amino acids. The arginine-fed rats also had higher levels of nitric oxide, an important marker of metabolic health. If these results apply to humans, taking arginine supplements might be useful in athletes trying to gain quality weight.


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